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Synaptic Systems
Recombinant antibodies – class winner in control

Dear Sigismund Huck,

Recombinant antibodies do have an advantage even to monoclonal antibodies regarding consistency and reproducibility. For a long time it was thought that monoclonal antibodies are the non-plus ultra in consistency and reproducibility, but over long time even hybridoma cell lines can experience genetic drift resulting in slightly decreased antibody affinity or even specificity. The genetic sequence of a recombinant antibody is known so factors which lead the genetic drift like gene mutations or gene loss can be easily counteracted. Besides the extreme low batch-to-batch variability the recombinant antibodies have more benefits like animal-free production or a switch to a new host species is easily possible.

All new recombinant antibodies are developed from very well-received mouse monoclonal antibodies with a long record of publications. We want to introduce to you, two Synaptotagmin 1 recombinant antibodies (originating from the clones 41.1 and 604.2), SNAP25 (clone 71.1), NeuN (clone 350G3), PSD95 (clone 108E10) and last but not least Homer 1 antibody (clone 2G8). All of these antibodies are chimeric monoclonal rabbit antibodies that are compatible with standard anti-rabbit secondary reagents.

The last new product is an affinity-purified Guinea pig polyclonal antibody against Amyloid Precursor protein (APP). APP shares many features with cell adhesion proteins. It is involved in neurite outgrowth, neuronal survival and synaptic plasticity but it is best-known as the precursor protein of the beta amyloid polypeptide that is the primary component of the plaques in brains of Alzheimer’s disease patients.

For a complete list of new products, please visit the News section.

IIndirect immunostaining of PFA fixed rat hippocampus neurons with monoclonal rabbit anti-SNAP25 (cat. no.:
111 008, dilution 1:1000; red) and monoclonal mouse
anti-Synapsin 1 (cat. no.: 106 011, dilution 1:1000; green). Nuclei have been visualized by DAPI staining (blue).

Indirect immunostaining of PFA fixed rat brain section with monoclonal rabbit anti-NeuN (cat. no.: 266 008, dilution 1:500; red). Nuclei have been visualized by DAPI staining (blue).
New SySy Antibodies

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  Synaptic Systems Gesellschaft fuer neurobiologische Forschung, Entwicklung und Produktion mbH
Rudolf-Wissell-Str. 28 | 37079 Goettingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: https://www.sysy.com | E-Mail: sales@sysy.com
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