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Spotlight on TRPV1 and BCAS1

  • The Transient receptor potential cation channel subfamily V member 1 (TRPV1), also referred to as capsaicin receptor or vanilloid receptor, is expressed mainly in sensory neurons of the peripheral and central nervous systems. It is activated by variety of exogenous and endogenous stimuli involved in nociception, e.g. heat, acidic conditions and capsaicin. We offer two new antibodies against TRPV1, one is directed to the cytoplasmic N-terminal domain, the other is targeted to the big extracellular loop near the C-terminus. Both display excellent results in IHC applications.
 
Indirect immunostaining of PFA fixed mouse spinal cord section with rabbit anti-TRPV1 extracellular domain (cat.no. 444 003, dilution 1:2000; red). Nuclei have been visualized by DAPI staining (blue).
 
  • BCAS1, or breast carcinoma amplified sequence 1, was originally identified as a potential oncogene amplified in human cancer cell lines. It is also highly expressed in brain where it mainly defines an oligodendroglial subpopulation occuring at regions of active myelin formation. In fetal brain BCAS1 positive oligodendrocytes are restricted to the white matter, in adult brains it can be found in the grey matter until old age. The antibody could be a interesting marker for regions of active myelination.
 
Indirect immunostaining of PFA fixed rat brain section with rabbit anti-BCAS1 (cat. no. 445 003, dilution 1:1000; red), Guinea pig anti-IBA1 (cat. no. 234 004, dilution 1:500; green) and chicken anti-GFAP (cat. no. 173 006, dilution 1:500; blue).
 
New recombinantly expressed rabbit monoclonal antibodies, species-switched from mouse monoclonals:
  • anti-GFAP; rabbit monoclonal antibody from clone 134B1
  • anti-GFAP; rabbit monoclonal antibody from clone 186C6
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Synaptic Systems Gesellschaft für neurobiologische Forschung, Entwicklung und Produktion mbH
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